This work illustrates for the first time the use of 111In-labelled PIC gels for diagnostic and monitoring purposes and describes the use of PIC in the (non-)splinted murine skin wound model. It was found that PIC gels remained in splinted and nonsplinted full-thickness skin wounds during wound repair.
Syntrix-BM kit can be used to prepare approximately 15 mL 3D cell culture matrix with embedded cells per kit.
Although common in biology, controlled stiffening of hydrogels in vitro is difficult to achieve; the required stimuli are commonly large and/or the stiffening amplitudes small. Here, we describe the hierarchical mechanics of ultra-responsive hybrid hydrogels composed of two synthetic networks, one semi-flexible and stress-responsive, the other flexible and thermoresponsive.
Meatable initiated the CLEANMEAT project in which the world’s first scalable method for production of cell-based meat is being developed. By using breakthrough patented single-cell technology, Meatable aims to ‘Feed the World with a single cell’. The scaffold to provide texture to the meat is being delivered by project partner Noviocell.
Hydrogels with low critical stress, cells are able to adhere and pull the PIC fibers, stiffen them and accumulate enough traction force for the observed morphological changes.
Kidney organoids are relevant from several perspectives, including modelling of kidney disease and injury. Commonly-used in vitro two-dimensional cell (2D) models are limited because cells behave differently in a 2D configuration and cannot constitute in vivo-relevant cell-cell interactions.
Full-thickness dorsal skin wounds in mice were treated with Noviogel for 3 and 7 days. No foreign body reaction, but even a significant decrease in granulocyte population in the wound was observed.