De identificatie van volwassen stamcellen uit weefsels heeft enorme mogelijkheden geopend voor de regeneratieve geneeskunde.
Kidney organoids are relevant from several perspectives, including modelling of kidney disease and injury. Commonly-used in vitro two-dimensional cell (2D) models are limited because cells behave differently in a 2D configuration and cannot constitute in vivo-relevant cell-cell interactions.
Noviogel hydrogels can be crosslinked after cell or organoid culture without loss of the reversible thermosensitive property during culture.
A robust and valid alternative to other commercial systems for the fabrication of 3D hydrogels to be used as an advanced platform in tissue engineering.
This recent study published in Acta Biomaterialia (2018) confirms that fibroblasts, endothelial cells, adipose-derived stem cells and melanoma cells, do survive, thrive and differentiate in optimized PIC hydrogels. They support the spontaneous formation of complex structures like blood capillaries in vitro.
Syntrix-BM kit can be used to prepare approximately 15 mL 3D cell culture matrix with embedded cells per kit.
• Syntrix-BM is highly transparent and compatible with multiple staining dyes and protocols employed in High Content Analysis, including stains for live cell analysis.
• Syntrix-BM supports High Content Analysis of cytotoxicity in a realistic 3D environment
• Syntrix-BM supports formation and analysis of 3D microtissues