Although common in biology, controlled stiffening of hydrogels in vitro is difficult to achieve; the required stimuli are commonly large and/or the stiffening amplitudes small. Here, we describe the hierarchical mechanics of ultra-responsive hybrid hydrogels composed of two synthetic networks, one semi-flexible and stress-responsive, the other flexible and thermoresponsive.
Meatable initiated the CLEANMEAT project in which the world’s first scalable method for production of cell-based meat is being developed. By using breakthrough patented single-cell technology, Meatable aims to ‘Feed the World with a single cell’. The scaffold to provide texture to the meat is being delivered by project partner Noviocell.
De identificatie van volwassen stamcellen uit weefsels heeft enorme mogelijkheden geopend voor de regeneratieve geneeskunde.
The short term primary prostate cancer patient derived organoids will be of great added value in early drug screens and personalized medicine, as in vitro testing of subsequent treatment options might predict patient responses and therefore allowing guidance of clinical decision making.
Kidney organoids are relevant from several perspectives, including modelling of kidney disease and injury. Commonly-used in vitro two-dimensional cell (2D) models are limited because cells behave differently in a 2D configuration and cannot constitute in vivo-relevant cell-cell interactions.
Full-thickness dorsal skin wounds in mice were treated with Noviogel for 3 and 7 days. No foreign body reaction, but even a significant decrease in granulocyte population in the wound was observed.
Noviogel hydrogels can be crosslinked after cell or organoid culture without loss of the reversible thermosensitive property during culture.