De identificatie van volwassen stamcellen uit weefsels heeft enorme mogelijkheden geopend voor de regeneratieve geneeskunde.
The short term primary prostate cancer patient derived organoids will be of great added value in early drug screens and personalized medicine, as in vitro testing of subsequent treatment options might predict patient responses and therefore allowing guidance of clinical decision making.
Kidney organoids are relevant from several perspectives, including modelling of kidney disease and injury. Commonly-used in vitro two-dimensional cell (2D) models are limited because cells behave differently in a 2D configuration and cannot constitute in vivo-relevant cell-cell interactions.
Full-thickness dorsal skin wounds in mice were treated with Noviogel for 3 and 7 days. No foreign body reaction, but even a significant decrease in granulocyte population in the wound was observed.
Noviogel hydrogels can be crosslinked after cell or organoid culture without loss of the reversible thermosensitive property during culture.
Op dit moment is Noviocell voor de ontwikkeling van Noviogel volgens Van den Dolder vooral op zoek naar investeerders om de stap naar het ontwikkelen van diagnostische 3D modellen te maken.
This recent study published in Acta Biomaterialia (2018) confirms that fibroblasts, endothelial cells, adipose-derived stem cells and melanoma cells, do survive, thrive and differentiate in optimized PIC hydrogels. They support the spontaneous formation of complex structures like blood capillaries in vitro.