Op dit moment is Noviocell voor de ontwikkeling van Noviogel volgens Van den Dolder vooral op zoek naar investeerders om de stap naar het ontwikkelen van diagnostische 3D modellen te maken.
This recent study published in Acta Biomaterialia (2018) confirms that fibroblasts, endothelial cells, adipose-derived stem cells and melanoma cells, do survive, thrive and differentiate in optimized PIC hydrogels. They support the spontaneous formation of complex structures like blood capillaries in vitro.
• Syntrix-BM is highly transparent and compatible with multiple staining dyes and protocols employed in High Content Analysis, including stains for live cell analysis.
• Syntrix-BM supports High Content Analysis of cytotoxicity in a realistic 3D environment
• Syntrix-BM supports formation and analysis of 3D microtissues
A newer approach for cell retrieval is based on temperature-responsive polymers, which reversibly alter their hydrophobic/hydrophilic nature in response to cultivation temperature.
Researchers at Maastricht University, Noviocell BV and Cell Guidance Systems Ltd are collaborating on an EU funded Eurostars project to develop fully-defined matrices for the 3D culture of organoids.
Complex diseases like cancer are more frequently being modelled using in vitro systems as more researchers opt for three-dimensional (3D) cell culture methods over two-dimensional (2D) ones. In some cases, 3D systems even have advantages over tumour xenograft models .
Cell biologists are slowly replacing two-dimensional (2D) cell culture with more advanced alternatives, such as growing cells in three-dimensions (3D) by their encapsulation in hydrogels. Unlike 2D cell culture, where cells adhere to the culture vessel’s flat, hard surfaces in monolayers, 3D systems facilitate a higher order of cellular spatial organization and thus yield more physiologically relevant information – a definite advantage if you are looking to put a potential therapeutic molecule through its paces.