Noviocell BV proposes a novel ground breaking technology that will radically improve stem cell research, revolutionize the field of 3D cell culture, will enable personalized drug screening and reform the current therapeutic options for regenerative medicine.

Noviogel (PIC) is a fully synthetic biomimetic extracellular matrix; however, it has almost identical biomechanical properties to natural matrices. The complex chemistry of the polymer allows the organization into a helix-like structure that is similar to the conformation of collagen, abundantly present in the ECM. In addition, the porous fibrous polymer network has a stiffness that increases under applied force similar to collagen or fibrin.

Technology Noviogel

Technology Noviogel The most basic units of life are cells. An adult is comprised of trillions of cells. Many diseases are related to cells, for example cancer cells with their uncontrolled cell growth. Stem cells are “unspecialized” cells in your body, which divide and become specialized cells such as liver cells, muscle cells, blood cells, or other cells. Therefore, stem cells are an exciting area in medicine because of their potential to regenerate and repair damaged tissue.

At the moment, several studies are ongoing in which design materials are used to induce stem cell differentiation within a 3D environment. However, it is very difficult to form three-dimensional artificial tissues similar to the structurally complex tissue within the human body due to the technical limits in biomaterials.

Drawbacks of the current matrices are poor reproducibility due to changes in composition between batches, animal origin and harsh method to recover cells from the matrix.

Poly iso cyano peptide (PIC) hydrogel is a new class of advanced polymers. The complex chemistry of the polymer allows the organization into a helix-like structure that is similar to the conformation of collagen, abundantly present in the extracellular matrix (structure around cells).

PIC hydrogel is an improved platform for cell studies, because it combines the unique benefits of natural and synthetic biomaterials. PIC hydrogels uniquely perform like collagen, while possessing the same characteristics as other commercial hydrogels. Furthermore, it is fully reversible thermo sensitive, cells can be easy recovered and downstream processing after culturing is straightforward.

The unique combination of tunable bio-functionality and biomechanics of the PIC hydrogels makes them excellent matrices for 3D stem cell culture or regenerative medicine.


In addition, PIC has a strain stiffness that increases under applied force, thereby enabling hydrogel strain stiffness modulation according to the needs of each cell type. Hereby, PIC hydrogels create a cellular microenvironment with the right mechanical cues to control cell expansion and differentiation.

Advantages of PIC hydrogel
No batch to batch variation - because of synthetic origin
Excellent cell growth and differentiation
Represents biomechanical properties similar to natural matrices - same elasticity as collagen
Easy to use - reversible thermosensitive:
• no difficulties in cell or organoid isolation
• no difficulties with downstream processing or imaging after culturing
Biofunctionality - by clicking (growth) factor of choice to the polymer


Noviocell will build upon its synthetic PIC hydrogels and develop them into easy-to-use solutions.

Drawbacks Natural matrices
Batch to batch variation - their exact composition cannot be defined
Pathogen transmission and immunogenicity
Technical challenges in handling - difficulties in cell or organoid isolation
Technical challenges with downstream processing after culturing - imaging
Experimental inertness - inability to experimentally vary composition
Due to their composition, they cannot be used for regenerative medicine
Drawbacks other Synthetic matrices
Do not adequately represent the complicated extracellular matrix
Limited cell growth and differentiation
Technical challenges in handling - difficulties in cell or organoid isolation
Technical challenges with downstream processing after culturing - imaging


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Unique reversible thermo-sensitive characteristics

Synthetic origin and no batch-to-batch variation

Bio-degradable and non-toxic

Elastic behavior as collagen

Bio-functional applications through custom-made specific hydrogels

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